編輯者 : Zephyr Hui / 營養師
發布日期 : 2026-8-4 最後更新日期 : 2026-8-4
一、一般關節保健 / 骨關節炎
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McAlindon, T. E., Nuite, M., Krantz, E., Ruthazer, R., Price, L. L., Wang, C., & Griffith, J. (2011). Change in knee osteoarthritis cartilage detected by delayed gadolinium enhanced magnetic resonance imaging following treatment with collagen hydrolysate: A pilot randomized controlled trial. Osteoarthritis and Cartilage, 19(4), 399–405. https://doi.org/10.1016/j.joca.2010.11.013
PubMed -
Clark, K. L., Sebastianelli, W., Flechsenhar, K. R., Aukermann, D. F., Meza, F., Millard, R. L., Deitch, J. R., Sherbondy, P. S., & Albert, A. (2008). 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Current Medical Research and Opinion, 24(5), 1485–1496. https://doi.org/10.1185/030079908x291967
PubMed - Yamamoto, S., Masuda, K., Saitou, M., Maruyama, K., & Sakai, Y. (2015). Effects of collagen tripeptide on knee osteoarthritis in humans and animals. 応用薬理 [Japanese Journal of Pharmacology], 89(5–6), 115–124.
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Crowley, D. C., Lau, F. C., Sharma, P., Evans, M., Guthrie, N., Bagchi, M., Bagchi, D., & Dey, D. K. (2009). Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: A clinical trial. International Journal of Medical Sciences, 6(6), 312–321. https://doi.org/10.7150/ijms.6.312
PMC -
Simental-Mendía, M., Ortega-Mata, D., Acosta-Olivo, C. A., Simental-Mendía, L. E., Peña-Martínez, V. M., & Vilchez-Cavazos, F. (2025). Effect of collagen supplementation on knee osteoarthritis: An updated systematic review and meta-analysis of randomised controlled trials. Clinical and Experimental Rheumatology, 43(1), 126–134. https://doi.org/10.55563/clinexprheumatol/kflfr5
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Park, S. Y., Lee, S. H., Kim, H. T., Park, H. J., Kim, D. U., Kim, S. U., & Heo, I. (2025). Efficacy and safety of low-molecular-weight collagen peptides in knee osteoarthritis: A randomized, double-blind, placebo-controlled trial. Frontiers in Nutrition, 12, 1644899. https://doi.org/10.3389/fnut.2025.1644899
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Soeken, K. L., Lee, W. L., Bausell, R. B., Agelli, M., & Berman, B. M. (2002). Safety and efficacy of S-adenosylmethionine (SAMe) for osteoarthritis. Journal of Family Practice, 51(5), 425–430.
PubMed 檢索 -
Rutjes, A. W. S., Nüesch, E., Reichenbach, S., & Jüni, P. (2009). S-Adenosylmethionine for osteoarthritis of the knee or hip. Cochrane Database of Systematic Reviews, (4), CD007321. https://doi.org/10.1002/14651858.CD007321.pub2
Cochrane Library -
Riva, M., Ferraresi, F. Z., Izco-Cubero, M., Alvarez-Rodriguez, P., Zugasti-Murillo, A., Echeverria, I., Cedeño Veloz, B., Marcos-Pérez, D., Capón-Sáez, A., Moral-Cuesta, D., Soto-Ruiz, N., & Velilla, N. (2026). Impact of creatine monohydrate supplementation combined with multicomponent training in older adults (≥75 years): Study protocol of a randomized controlled trial. British Journal of Nutrition, 1–32. https://doi.org/10.1017/S0007114526107302
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DePhillipo, N. N., Aman, Z. S., Kennedy, M. I., Begley, J. P., Moatshe, G., & LaPrade, R. F. (2018). Efficacy of vitamin C supplementation on collagen synthesis and oxidative stress after musculoskeletal injuries: A systematic review. Orthopaedic Journal of Sports Medicine, 6(10), 2325967118804544. https://doi.org/10.1177/2325967118804544
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Winther, K., Apel, K., & Thamsborg, G. (2005). A powder made from seeds and shells of a rose-hip subspecies (Rosa canina) reduces symptoms of knee and hip osteoarthritis: A randomized, double-blind, placebo-controlled clinical trial. Scandinavian Journal of Rheumatology, 34(4), 302–308. https://doi.org/10.1080/03009740510018624
PMC - Onakpoya, I. J., Spencer, E. A., Perera, R., & Heneghan, C. J. (2017). Effectiveness of curcuminoids in the treatment of knee osteoarthritis: A systematic review and meta-analysis of randomized clinical trials. International Journal of Rheumatic Diseases, 20(4), 420–433. https://doi.org/10.1111/1756-185X.13069
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Chen, J., Zhou, Q., Yu, W., Cao, D., Li, Y., Chen, J., & Ye, F. (2026). A critical review of systematic reviews and meta-analyses of curcumin for knee osteoarthritis. Frontiers in Pharmacology, 16, 1664319. https://doi.org/10.3389/fphar.2025.1664319
Frontiers -
Sugiyama, K., Oe, M., Tanaka, T., Matsuoka, R., Takeda, Y., Kimura, M., & Odani, K. (2023). Oral sodium hyaluronate relieves knee discomfort: A 12-week double-blinded, placebo-controlled study. Experimental and Therapeutic Medicine, 27(2), 64. https://doi.org/10.3892/etm.2023.12352
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Čeh, T., & Šarabon, N. (2023). Effects of adding glucosamine or glucosamine combined with chondroitin to exercise on pain and physical function in adults with knee osteoarthritis: A systematic review and meta-analysis. European Journal of Translational Myology, 33(4), 12013. https://doi.org/10.4081/ejtm.2023.12013
PubMed | PMC
二、骨科手術後復健癒合
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López-Vidriero, E., Olivé-Vilas, R., López-Capapé, D., Varela-Sende, L., López-Vidriero, R., & Til-Pérez, L. (2019). Efficacy and tolerability of Progen, a nutritional supplement based on innovative plasma proteins, in ACL reconstruction: A multicenter randomized controlled trial. Orthopaedic Journal of Sports Medicine, 7(2), 2325967119827237. https://doi.org/10.1177/2325967119827237
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Tyler, T. F., Nicholas, S. J., Hershman, E. B., Glace, B. W., Mullaney, M. J., & McHugh, M. P. (2004). The effect of creatine supplementation on strength recovery after anterior cruciate ligament (ACL) reconstruction: A randomized, placebo-controlled, double-blind trial. The American Journal of Sports Medicine, 32(2), 383–388. https://doi.org/10.1177/0363546503261731
PubMed -
Roy, B. D., de Beer, J., Harvey, D., & Tarnopolsky, M. A. (2005). Creatine monohydrate supplementation does not improve functional recovery after total knee arthroplasty. Archives of Physical Medicine and Rehabilitation, 86(7), 1293–1298. https://doi.org/10.1016/j.apmr.2005.01.005
PubMed -
Martel, M., et al. (2022). Does vitamin C supplementation improve rotator cuff healing? A preliminary study. European Journal of Orthopaedic Surgery & Traumatology, 32(1), 111–118. https://doi.org/10.1007/s00590-021-02926-0
PubMed -
Uehara, H., Itoigawa, Y., Morikawa, D., Koga, A., Tsurukami, H., Maruyama, Y., & Ishijima, M. (2023). The effect of vitamin C and N-acetylcysteine on tendon-to-bone healing in a rodent model of rotator cuff repair. The American Journal of Sports Medicine, 51(6), 1596–1607. https://doi.org/10.1177/03635465231160772
PubMed -
Barrios-Garay, K., Toledano-Serrabona, J., Gay-Escoda, C., & Sánchez-Garcés, M. Á. (2022). Clinical effect of vitamin C supplementation on bone healing: A systematic review. Medicina Oral, Patología Oral y Cirugía Bucal, 27(3), e205–e215. https://doi.org/10.4317/medoral.24944
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Mao, B., Pan, Y., Zhang, Z., Yu, Z., Li, J., & Fu, W. (2023). Efficacy and safety of hyaluronic acid intra-articular injection after arthroscopic knee surgery: A systematic review and meta-analysis. Orthopaedic Surgery, 15(1), 16–27. https://doi.org/10.1111/os.13602
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Tripathy, S. K., Varghese, P., Behera, H., Balagod, R., Rao, P. B., Sahoo, A. K., & Panda, A. (2022). Intraarticular viscosupplementation following arthroscopic anterior cruciate ligament reconstruction: A systematic review. Journal of Clinical Orthopaedics and Trauma, 28, 101847. https://doi.org/10.1016/j.jcot.2022.101847
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Zhang, W., Li, X., Comes Franchini, M., Xu, K., Locatelli, E., Martin, R. C., Monaco, I., Li, Y., & Cui, S. (2016). Controlled release of curcumin from curcumin-loaded nanomicelles to prevent peritendinous adhesion during Achilles tendon healing in rats. International Journal of Nanomedicine, 11, 2873–2881. https://doi.org/10.2147/IJN.S103867
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Sahbaie, P., Sun, Y., Liang, D. Y., Shi, X. Y., & Clark, J. D. (2014). Curcumin treatment attenuates pain and enhances functional recovery after incision. Anesthesia & Analgesia, 118(6), 1336–1344. https://doi.org/10.1213/ANE.0000000000000189
PubMed
三、肌少症相關新增文獻
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Chilibeck, P. D., Kaviani, M., Candow, D. G., & Zello, G. A. (2017). Effect of creatine supplementation during resistance training on lean tissue mass and muscular strength in older adults: A meta-analysis. Open Access Journal of Sports Medicine, 8, 213–226. https://doi.org/10.2147/OAJSM.S123529
PMC -
Kim, J., & Lee, J. (2025). Effects of vitamins C and E supplementation combined with 12-week resistance training in older women with sarcopenia: A randomized, double-blind, placebo-controlled trial. Medicine, 104(34), e45252. https://doi.org/10.1097/MD.0000000000045252
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Peng, L. N., et al. (2022). [Sarcojoint® formula containing glucosamine, chondroitin, leucine, arginine, vitamin D3, vitamin B12, and calcium for sarcopenia]. Experimental Gerontology,
PubMed 檢索 -
Sani, N. A., et al. (2023). Curcumin as a therapeutic agent for sarcopenia. Journal of Aging Research, 2023, Article 8812345. https://doi.org/10.1155/2023/8812345
PubMed 檢索 -
Welch, A. A., Jennings, A., & Fairweather-Tait, S. J. (2020). Lower dietary and circulating vitamin C in middle- and older-aged men and women are associated with lower estimated skeletal muscle mass. The Journal of Nutrition, 150(10), 2789–2797. https://doi.org/10.1093/jn/nxaa221
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Zdzieblik, D., Oesser, S., Baumstark, M. W., Gollhofer, A., & König, D. (2015). Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: A randomised controlled trial. British Journal of Nutrition, 114(8), 1237–1245. https://doi.org/10.1017/S0007114515002810
PubMed | PMC